Diagnosis of Parkinson disease (PD) currently relies on clinical symptoms, and is often made late into the disease. Immunostaining for α-synuclein in gastric mucosa samples might aid earlier diagnosis of PD, a new study shows. Mucosa biopsies were positive for α-synuclein in 17 of 28 patients with PD, one of six individuals with mild presymptomatic parkinsonism, and only one of 23 healthy controls.
References
Sánchez-Ferro, Á. et al. In vivo gastric detection of α-synuclein inclusions in Parkinson's disease. Mov. Disord. 110.1002/mds.25988
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Detection of α-synuclein inclusions in the gastric mucosa of patients with PD could hasten diagnosis. Nat Rev Neurol 10, 486 (2014). https://doi.org/10.1038/nrneurol.2014.157
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DOI: https://doi.org/10.1038/nrneurol.2014.157