Gilles de la Tourette syndrome (GTS) is often perceived as the 'swearing disease', yet coprolalia affects only 10–15% of individuals with this condition. As highlighted in a new study, GTS has many phenotypes, some of which are sex-related. Could gender—that is, culturally established roles—also affect the phenotype?
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References
Rodgers, S. et al. Sex-related and non-sex-related comorbidity subtypes of tic disorders: a latent class analysis. Eur. J. Neurol. http://dx.doi.org/10.1111/ene.12274.
Robertson, M. M. & Eapen, V. Whither the relationship between aetiology and phenotype in Tourette syndrome? In Tourette Syndrome (eds Leckman, J. F. & Martino, D.) 361–394 (Oxford University Press, 2013).
Eapen, V., O'Neill, J., Gurling, H. M. & Robertson, M. M. Sex of parent transmission effect in Tourette's syndrome: evidence for earlier age at onset in maternally transmitted cases suggests a genomic imprinting effect. Neurology 48, 934–937 (1997).
Robertson, M. M. The Gilles de la Tourette syndrome: the current status. Arch. Dis. Child. Educ. Pract. Ed. 97, 166–175 (2012).
Knight, T. et al. Prevalence of tic disorders: a systematic review and meta-analysis. Pediatr. Neurol. 47, 77–90 (2012).
Eapen, V., Fox-Hiley, P., Banerjee, S. & Robertson, M. M. Clinical features and associated psychopathology in a Tourette Syndrome cohort. Acta Neurol. Scand. 109, 255–260 (2004).
Robertson, M. M. & Cavanna, A. E. The Gilles de la Tourette syndrome: a principal component factor analytic study of a large pedigree. Psychiatr. Genet. 17, 143–152 (2007).
Robertson, M. M. Mood disorders and Gilles de la Tourette's syndrome: an update on prevalence, etiology, comorbidity, clinical associations, and implications. J. Psychosom. Res. 61, 349–358 (2006).
Rizzo, R., Gulisano, M., Cali, P. V. & Curatolo, P. Long term clinical course of Tourette syndrome. Brain Dev. 34, 667–673 (2012).
Ganos, C. et al. Are premonitory urges a prerequisite of tic inhibition in Gilles de la Tourette syndrome? J. Neurol. Neurosurg. Psychiatry 83, 975–978 (2012).
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Supplementary Table 1
Studies showing different phenotypes (factors, classes, clusters) in GTS and some aetiological suggestions (DOC 66 kb)
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Robertson, M. Tourette syndrome—beyond swearing and sex?. Nat Rev Neurol 10, 6–8 (2014). https://doi.org/10.1038/nrneurol.2013.248
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DOI: https://doi.org/10.1038/nrneurol.2013.248
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