Patients with optic neuritis are at an increased risk of developing multiple sclerosis (MS) compared with the general population, but prognostic markers for this conversion are lacking. Researchers in Denmark analyzed the cerebrospinal fluid (CSF) of 66 patients with optic neuritis and/or MS. They found that CSF levels of tau protein were significantly increased in patients with optic neuritis who went on to convert to MS, but not in patients with monosymptomatic optic neuritis.
ORIGINAL RESEARCH PAPER
Frederiksen, J. et al. Tau protein: a possible prognostic factor in optic neuritis and multiple sclerosis. Mult. Scler. doi:10.1177/1352458511424588
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Tau as a prognostic marker of progression from optic neuritis to multiple sclerosis. Nat Rev Neurol 7, 656 (2011). https://doi.org/10.1038/nrneurol.2011.181
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DOI: https://doi.org/10.1038/nrneurol.2011.181
