A pathophysiologic link exists between proteinuria and renal phosphate handling, say researchers. An analysis of 1,738 patients with chronic kidney disease identified albuminuria ≥300 mg per 24 h as an independent predictor of high phosphate levels. Using both rat and mouse animal models, the researchers showed that proteinuria-induced phosphate retention was partly caused by enhanced sodium-dependent phosphate transport protein 2A expression and decreased fibroblast growth factor (FGF)-23 activity. They suggest that high levels of phosphate and FGF-23 in patients with proteinuria might contribute to their increased risk of cardiovascular disease.
References
de Seigneux, S. et al. Proteinuria increases plasma phosphate by altering its tubular handling. J. Am. Soc. Nephrol. 10.1681/ASN.2014010104
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Proteinuria increases phosphate retention. Nat Rev Nephrol 11, 2 (2015). https://doi.org/10.1038/nrneph.2014.214
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DOI: https://doi.org/10.1038/nrneph.2014.214