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Xenotransplantation and other means of organ replacement

Nature Reviews Immunology volume 1, pages 154–160 (2001)Cite this article

Abstract

Exciting new technologies, such as cellular transplantation, organogenesis and xenotransplantation, are thought to be promising approaches for the treatment of human disease. The feasibility of applying these technologies, however, might be limited by biological and immunological hurdles. Here, we consider whether, and how, xenotransplantation and various other technologies might be applied in future efforts to replace or supplement the function of human organs and tissues.

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Figure 1: Biological responses to xenotransplantation.
Figure 2: The pathogenesis of acute vascular rejection.

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Acknowledgements

Work in the laboratories of the authors is supported by grants from the National Institutes of Health and by the Von Liebig Foundation.

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Authors and Affiliations

  1. Transplantation Biology and the Departments of Surgery and Immunology, Medical Sciences Building 2–66, 200 1st Street SW, Mayo Clinic, Rochester, 55905, Minnesota, USA

    Marilia Cascalho & Jeffrey L. Platt

  2. Department of Pediatrics, Medical Sciences Building 2–66, 200 1st Street SW, Mayo Clinic, Rochester, 55905, Minnesota, USA

    Marilia Cascalho & Jeffrey L. Platt

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  1. Marilia Cascalho
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  2. Jeffrey L. Platt
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Correspondence to Jeffrey L. Platt.

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DATABASES

LocusLink

BCL2

CD55

CD59

E-selectin

HO-1

IL-1α

IL-1β

IL-1R

PAI-1

FURTHER INFORMATION

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Glossary

ALLOGENEIC

Of, or relating to, the same species; for example, allogeneic transplants are transplants between individuals of the same species.

ISCHAEMIA

A condition in which the flow of blood to a tissue or organ is less than normal, and which results in injury to that tissue or organ.

ISLETS OF LANGERHANS

The tissue of the pancreas that contains endocrine cells, including the β-cells that secrete insulin.

SUBSTANTIA NIGRA

A part of the brain affected by Parkinson's disease.

XENOGENEIC

Of, or relating to, a foreign species.

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Cascalho, M., Platt, J. Xenotransplantation and other means of organ replacement. Nat Rev Immunol 1, 154–160 (2001). https://doi.org/10.1038/35100578

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