Abstract
Twenty years of investigation have yielded a detailed view of the signalling machinery engaged by T-cell receptors (TCRs). Many of the fundamental insights into TCR signalling came from studies carried out with transformed T-cell lines. Perhaps the best known of these model systems is the Jurkat leukaemic T-cell line, and here we review some of the key advances in the field of TCR signalling that were made with Jurkat T cells as the host.
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We thank the reviewers for their helpful comments, and apologize to the many investigators whose valuable contributions have not been cited due to space constraints.
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Abraham, R., Weiss, A. Jurkat T cells and development of the T-cell receptor signalling paradigm. Nat Rev Immunol 4, 301–308 (2004). https://doi.org/10.1038/nri1330
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DOI: https://doi.org/10.1038/nri1330
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