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Epigenetics and metabolism in 2014

Metabolic programming—knowns, unknowns and possibilities

Nature Reviews Endocrinology volume 11, pages 67–68 (2015)Cite this article

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Studies published in 2014 have helped in our understanding of the epigenetic mechanisms by which suboptimal nutritional exposures during in utero development are transmitted to subsequent generations through the maternal and the paternal germlines. Advances include identification of common genetic loci that are vulnerable to the effects of in utero undernutrition and overnutrition, as well as those that are epigenetically modified tissue-wide.

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Acknowledgements

The author is supported by grants from the British Heart Foundation (PG/13/46/30329), Diabetes UK (12/0004508), the European Union (Seventh Framework Programme EarlyNutrition under grant agreement number 289,346) and Medical Research Council (MRC_MC_UU_12012/4).

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Authors and Affiliations

  1. University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Level 4, Institute of Metabolic Science, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK

    Susan E. Ozanne

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  1. Susan E. Ozanne
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Correspondence to Susan E. Ozanne.

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Ozanne, S. Metabolic programming—knowns, unknowns and possibilities. Nat Rev Endocrinol 11, 67–68 (2015). https://doi.org/10.1038/nrendo.2014.218

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