Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Therapy

Low-dose aspirin to reduce the risk of pre-eclampsia?

Numerous studies have evaluated the use of low-dose aspirin (LDA) to reduce rates of pre-eclampsia and adverse perinatal outcomes in women considered at risk of pre-eclampsia. A new study recommends that these women should receive LDA after 12 weeks of gestation to reduce the rates of pre-eclampsia, preterm birth and fetal growth restriction.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. American College of Obstetricians and Gynecologists; Task Force on Hypertension in Pregnancy. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists' Task Force on Hypertension in Pregnancy. Obstet. Gynecol. 122, 1122–1131 (2013).

  2. Barton, J. R. & Sibai, B. M. Prediction and prevention of recurrent preeclampsia. Obstet. Gynecol. 112, 359–372 (2008).

    Article  Google Scholar 

  3. Meher, S. & Alfirevic, Z. Aspirin for pre-eclampsia; beware of subgroup meta-analysis. Ultrasound Obstet. Gynecol. 41, 479–485 (2013).

    Article  CAS  Google Scholar 

  4. Askie, L. M., Duley, L., Henderson-Smart, D. J., Stewart, L. A. & PARIS Collaborative Group. Antiplatelet agents for prevention of pre-eclampsia: a meta-analysis of individual patient data. Lancet 369, 1791–1798 (2007).

    Article  CAS  Google Scholar 

  5. LeFevre, M. L. Low-dose aspirin use for the prevention of morbidity and mortality from preeclampsia: U.S. Preventative Task Force recommendation statement. Ann. Intern. Med. http://dx.doi.org/10.7326/M14-1884.

  6. [No authors listed] CLASP: a randomized trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9,364 pregnant women. CLASP (Collaborative Low-dose Aspirin Study in Pregnancy) Collaborative Group. Lancet 343, 619–629 (1994).

  7. [No authors listed] ECPPA: randomised trial of low dose aspirin for the prevention of maternal and fetal complications in high risk pregnant women. ECPPA (Estudo Colaborativo para Prevenção da Pré-eclampsia com Aspirina) Collaborative Group. Br. J. Obstet. Gynaecol. 103, 39–47 (1996).

  8. Caritis, S. et al. Low-dose aspirin to prevent preeclampsia in women at high risk. National Institute of Child. Health and Human Development Network of Maternal–Fetal Medicine Units. N. Engl. J. Med. 338, 701–705 (1998).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The author wishes to acknowledge his assistant A. I. Rosas.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Baha M. Sibai.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sibai, B. Low-dose aspirin to reduce the risk of pre-eclampsia?. Nat Rev Endocrinol 11, 6–8 (2015). https://doi.org/10.1038/nrendo.2014.199

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrendo.2014.199

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing