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Thyroid disease in pregnancy in 2011

Thyroid function—effects on mother and baby unraveled

The complex relationship between pregnancy and thyroid function, and its clinical effect on mother and baby, continued to stimulate research in 2011. Key advances were made on three important issues: how long maternal thyroid function affects fetal thyroid hormone levels; whether thyroid autoimmunity affects pregnancy outcome; and the prevalence of permanent hypothyroidism after postpartum thyroiditis.

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References

  1. Kuppens, S. M. et al. Neonatal thyroid screening results are related to gestational maternal thyroid function. Clin. Endocrinol. (Oxf.) 75, 382–387 (2011).

    Article  CAS  Google Scholar 

  2. Oken, E. et al. Neonatal thyroxine, maternal thyroid function, and child cognition. J. Clin. Endocrinol. Metab. 94, 497–503 (2009).

    Article  CAS  PubMed  Google Scholar 

  3. Shields, B. M., Knight, B. A., Hill, A., Hattersley, A. T. & Vaidya, B. Fetal thyroid hormone level at birth is associated with fetal growth. J. Clin. Endocrinol. Metab. 96, E934–E938 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Bassett, J. H. et al. A lack of thyroid hormones rather than excess thyrotropin causes abnormal skeletal development in hypothyroidism. Mol. Endocrinol. 22, 501–512 (2008).

    Article  CAS  PubMed  Google Scholar 

  5. Vanderpump, M. P. et al. Iodine status of UK schoolgirls: a cross-sectional survey. Lancet 377, 2007–2012 (2011).

    Article  CAS  PubMed  Google Scholar 

  6. Weetman, A. P. Immunity, thyroid function and pregnancy: molecular mechanisms. Nat. Rev. Endocrinol. 6, 311–318 (2010).

    Article  CAS  PubMed  Google Scholar 

  7. Negro, R. et al. Thyroid antibody positivity in the first trimester of pregnancy is associated with negative pregnancy outcomes. J. Clin. Endocrinol. Metab. 96, E920–E924 (2011).

    Article  CAS  PubMed  Google Scholar 

  8. Stagnaro-Green, A. et al. High rate of persistent hypothyroidism in a large-scale prospective study of postpartum thyroiditis in southern Italy. J. Clin. Endocrinol. Metab. 96, 652–657 (2011).

    Article  CAS  PubMed  Google Scholar 

  9. Stuckey, B. G. et al. Low urinary iodine postpartum is associated with hypothyroid postpartum thyroid dysfunction and predicts long-term hypothyroidism. Clin. Endocrinol. (Oxf.) 74, 631–635 (2011).

    Article  CAS  Google Scholar 

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Weetman, A. Thyroid function—effects on mother and baby unraveled. Nat Rev Endocrinol 8, 69–70 (2012). https://doi.org/10.1038/nrendo.2011.217

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  • DOI: https://doi.org/10.1038/nrendo.2011.217

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