A recent report has identified uroguanylin as an endocrine signal that exerts a physiological role in energy homeostasis, adding another factor to the gut–brain axis. From a clinical point of view, several observations highlight the uroguanylin–guanylyl cyclase C pathway as a potential therapeutic target for the development of antiobesity drugs.
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Frühbeck, G. Uroguanylin—a new gut-derived weapon against obesity?. Nat Rev Endocrinol 8, 5–6 (2012). https://doi.org/10.1038/nrendo.2011.206
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DOI: https://doi.org/10.1038/nrendo.2011.206
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