Urinary levels of the RNA oxidation marker 8-oxo-7,8-dihydroguanosine (8-oxoGuo) measured in 1,381 patients newly diagnosed as having type 2 diabetes mellitus predicted mortality after a median follow-up period of 18.7 years. The hazard ratios for patients in the highest 8-oxoGuo quartile compared with patients in the lowest quartile were 1.44 (1.12–1.85) for all-cause mortality and 1.54 (1.13–2.10) for diabetes-related mortality. No relationship was found between urinary levels of a marker of DNA oxidation and mortality in this population.
ORIGINAL RESEARCH PAPER
Broedbaek, K. et al. Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patients. Diabetes Care doi:10.2337/dc11-1620
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RNA oxidation marker predicts long-term mortality in T2DM. Nat Rev Endocrinol 8, 4 (2012). https://doi.org/10.1038/nrendo.2011.201
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DOI: https://doi.org/10.1038/nrendo.2011.201
