Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Parathyroid gland

Hyperparathyroidism in MEN1 syndrome: time to operate?

A novel report in the Journal of Bone and Mineral Research describes the aggressiveness of primary hyperparathyroidism associated with multiple endocrine neoplasia type 1 (MEN1) syndrome on kidney and bone complications. Will these findings influence the future management of parathyroid disease in patients with MEN1 syndrome?

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Wermer, P. Genetic aspects of adenomatosis of endocrine glands. Am. J. Med. 16, 363–371 (1954).

    Article  CAS  Google Scholar 

  2. Brandi, M. L. et al. Guidelines for diagnosis and therapy of MEN 1 type 1 and type 2. J. Clin. Endocrinol. Metab. 86, 5658–5671 (2001).

    Article  CAS  Google Scholar 

  3. Brandi, M. L., Marx, S. J., Aurbach, G. D. & Fitzpatrick, L. A. Familial multiple endocrine neoplasia type 1: a new look at pathophysiology. Endocr. Rev. 4, 391–405 (1987).

    Article  Google Scholar 

  4. Doherty, G. M. et al. Lethality of multiple endocrine neoplasia type I. World J. Surg. 22, 581–587 (1998).

    Article  CAS  Google Scholar 

  5. Lourenço, D. M. Jr et al. Early-onset, progressive, frequent, extensive and severe bone mineral and renal complications in multiple endocrine neoplasia type 1-associated primary hyperparathyroidism. J. Bone Miner. Res. doi:10.1002/jbmr.125.

  6. Burgess, J. R., David, R. Greenaway, T. M., Parameswaran, V. & Shepherd, J. J. Osteoporosis in multiple endocrine neoplasia type 1: severity, clinical significance, relationship to primary hyperparathyroidism, and response to parathyroidectomy. Arch. Surg. 134, 1119–1123 (1999).

    Article  CAS  Google Scholar 

  7. Lourenço, D. M. Jr et al. Multiple endocrine neoplasia type 1 in Brazil: MEN1 founding mutation, clinical features, and bone mineral density profile. Eur. J. Endocrinol. 159, 259–274 (2008).

    Article  Google Scholar 

  8. Coutinho, F. L. et al. Bone mineral density analysis in patients with primary hyperparathyroidism associated with multiple endocrine neoplasia type 1 after total parathyroidectomy. Clin. Endocrinol. (Oxf.). 72, 462–468 (2010).

    Article  Google Scholar 

  9. Christopoulos, C., Antoniou, N., Thempeyioti, A., Calender, A. & Economopoulos, P. Familial multiple endocrine neoplasia type I: the urologist is first on the scene. BJU Int. 96, 884–887 (2005).

    Article  Google Scholar 

  10. Tham, E. et al. Clinical testing for mutations in the MEN1 gene in Sweden: A report on 200 unrelated cases. J. Clin. Endocrinol. Metab. 92, 3389–3395 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Ethics declarations

Competing interests

The author declares an association with the following companies: Amgen (consultant; grant/research support), Eli Lilly (grant/research support), Merck, Sharp and Dohme (consultant), Novartis (consultant; grant/research support), Sevier (consultant; grant/research support), Warner Chilcott (grant/research support).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brandi, M. Hyperparathyroidism in MEN1 syndrome: time to operate?. Nat Rev Endocrinol 6, 604–605 (2010). https://doi.org/10.1038/nrendo.2010.131

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrendo.2010.131

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer