Aspirin is probably the most commonly used drug worldwide and has major analgesic, antipyretic and antiplatelet activities. Data from the Physicians' Health Study now suggest that regular use of low-dose aspirin might help reduce the risk of type 2 diabetes mellitus by around 14% in otherwise healthy men.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Haffner, S. M., Lehto, S., Rönnemaa, T., Pyörälä, K. & Laakso, M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior history of myocardial infarction. N. Engl. J. Med. 339, 229–234 (1998).
Hundal, R. S. et al. Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. J. Clin. Invest. 109, 1321–1326 (2002).
Ridker, P. M. et al. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N. Engl. J. Med. 336, 973–979 (1997).
Hayashino, Y., Hennekens, C. H. & Kurth, T. Aspirin use and risk of type 2 diabetes in apparently healthy men. Am. J. Med. 122, 374–379 (2009).
Manrique, C., Lastra, G., Palmer, J., Gardner, M. & Sowers, J. R. Aspirin and diabetes mellitus: revisiting an old player. Ther. Adv. Cardiovasc. Dis. 2, 37–42 (2008).
Angiolillo, D. J. et al. Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment. J. Am. Coll. Cardiol. 48, 298–304 (2006).
Shoelson, S. E., Lee, J. & Yuan, M. Inflammation and the IKK β/I κ B/NF-κ B axis in obesity- and diet-induced insulin resistance. Int. J. Obes. Relat. Metab. Disord. 27 (Suppl. 3), S49–S52 (2003).
Kim, J. K. et al. Prevention of fat-induced insulin resistance by salicylate. J. Clin. Invest. 108, 437–446 (2001).
Gao, Z., Zuberi, A., Quon, M. J., Dong, Z. & Ye, J. Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases. J. Biol. Chem. 278, 24944–24950 (2003).
Möhlig, M. et al. Acetylsalicylic acid improves lipid-induced insulin resistance in healthy men. J. Clin. Endocrinol. Metab. 91, 964–967 (2006).
Acknowledgements
The authors acknowledge the assistance of James R. Sowers of the University of Missouri–Columbia School of Medicine in the preparation of this manuscript.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Lastra, G., Whaley-Connell, A. Aspirin and prevention of diabetes still a topic of debate. Nat Rev Endocrinol 5, 365–366 (2009). https://doi.org/10.1038/nrendo.2009.109
Issue Date:
DOI: https://doi.org/10.1038/nrendo.2009.109