●Strategies for disease modification in Alzheimer's disease. Citron, M. Nature Reviews Neuroscience September (2004)

●Special focus: antimicrobial strategies.Nature Reviews Microbiology September (2004) Articles include:

●Seeing is believing: the impact of structural genomics on antimicrobial discovery. Schmid, M. B.

●Passive antibody therapy for infectious diseases. Casadevall, A. Dadachova, E. & Pirofski, L. -A.

●Antivirals and antiviral strategies. De Clercq, E.

●Antiprion immunotherapy: to suppress or to stimulate? Aguzzi, A. & Sigurdson, C. J. Nature Reviews Immunology September (2004)

●RNAi quashes polyQ Caplen, N. J. Nature Biotechnology August (2004) A News and Views piece on a paper showing that RNA interference as therapy for neurodegenerative disease leads to improvements in cellular and behavioural abnormalities in a mouse model of spinocerebellar ataxia.

●Zooming in and out with quantum dots Jain, R. K. & Stroh, M. Nature Biotechnology August (2004) Multifunctional nanoparticle probes based on semiconductor quantum dots show promise for in vivo cancer targeting and imaging.

●Breast cancer progression with a Twist Thiery, J. P. & Morgan, M. Nature Medicine August (2004)

●Treating cancer's kinase 'addiction' Baselga, J. & Arribas, J. Nature Medicine August (2004)

●Redesigner drugs Dove, A. Nature Biotechnology August (2004)

●The articles listed below were published in Nature Reviews Genetics (September 2004) to form a joint Focus on Pharmacogenetics that includes articles in this issue of Nature Reviews Drug Discovery

●Pharmacogenetics and drug development: prospective pipeline strategies for safer and more effective drugs. Roses, A.

●Genetically modified mouse models for pharmacogenomics research. Liggett, S. B.

●Integrating pharmacogenetics into society: in search of a model. Webster, A., Martin, P., Lewis, G. & Smart, A.

●Pharmacogenetics — five decades of therapeutic lessons from genetic diversity. Meyer, U. A.

●Pharmacogenetics: ethical problems and solutions. Breckenridge, A., Lindpaintner, K., Lipton, P., McLeod, H., Rothstein, M. & Wallace, H.