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Psychedelic drugs: the ups and downs of ecstasy. Check, E. Nature 13 May (2004)

Next-generation protein drugs. Tomlinson, I. M. Nature Biotechnology May (2004)

Polio eradication, cessation of vaccination and re-emergence of disease. Minor, P. D. Nature Reviews Microbiology June (2004)

Exploiting tumour hypoxia in cancer treatment. Brown, J. M. & Wilson, W. R. Nature Reviews Cancer June (2004)

Structure-aided drug design's next generation. Thiel, K. A. Nature Biotechnology May (2004)

Can innate immunity be enhanced to treat microbial infections? Finlay, B. B. & Hancock, R. E. W. Nature Reviews Microbiology June (2004)

Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40. Sugamura, K., Ishii, N. & Weinberg, A. D. Nature Reviews Immunology June (2004)

Tracking and teaching. Hadley, C. EMBO Reports June (2004) Rather than waiting for new drugs, surveillance and education might be more efficient strategies to combat antimicrobial resistance.

The potential of positron-emission tomography to study anticancer-drug resistance. West, C. M. L., Jones, T. & Price, P. Nature Reviews Cancer June (2004)

Finally, mice with CF lung disease. Frizzell, R. A. & Pilewski, J. M. Nature Medicine May (2004)

LIFE and SCOPE: what guidance do they offer alongside ALLHAT and ANBP2? Nicholls, M. G. Journal of Human Hypertension May (2004)

Yeast as a model system for anticancer drug discovery. Simon, J. A. & Bedalov, A. Nature Reviews Cancer June (2004)

The anti-angiogenic basis of metronomic chemotherapy. Kerbel, R. S. & Kamen, B. A. Nature Reviews Cancer June (2004)