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Heart failure

A SHIFT from ion channels to clinical practice

Nature Reviews Cardiology volume 7, pages 669–670 (2010)Cite this article

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The 'funny' current (If) has been the subject of 30 years of laboratory research and is an important therapeutic target in heart disease owing to its effects on heart rate. SHIFT, a trial in patients with all-cause heart failure, shows that If inhibition reduces combined mortality and rate of hospitalization and opens further avenues of research and therapeutic challenges.

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Figure 1: 30 years of research in pacemaker (If) channel physiology have led to substantial translation into clinical practice.

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Authors and Affiliations

  1. Imperial College London, Harefield Heart Science Center, Harefield Hospital, Hill End Road, Harefield, UB9 6JH, Middlesex, UK

    Cesare M. Terracciano & Magdi H. Yacoub

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  1. Cesare M. Terracciano
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  2. Magdi H. Yacoub
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Correspondence to Magdi H. Yacoub.

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The authors declare no competing financial interests.

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Terracciano, C., Yacoub, M. A SHIFT from ion channels to clinical practice. Nat Rev Cardiol 7, 669–670 (2010). https://doi.org/10.1038/nrcardio.2010.179

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