Miltra et al. investigated whether microRNA (miRNA) expression is altered in cancer-associated fibroblasts (CAFs) isolated from patients with ovarian cancer. They found that miR-31 and miR-214 were downregulated and that miR-155 was upregulated. Mimicking these changes in normal fibroblasts resulted in their conversion to a CAF-like phenotype, and blocking these miRNA alterations in CAFs reverted them to a normal phenotype. Gene expression profiling revealed alterations in the expression of chemokine genes, including CCL5, which the authors found to be a target of miR-214.