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Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation

Nature Reviews Cancer volume 7, pages 409–413 (2007)Cite this article

Abstract

Recent studies have shown that three major tumour-suppressor proteins undergo monoubiquitylation-mediated nuclear–cytoplasmic shuttling. Importantly, this mechanism has consequences for cancer and implies that proper localization is central to the function of tumour suppressors. This Progress article highlights recent efforts demonstrating that monoubiquitylation coupled to nuclear–cytoplasmic shuttling might be a novel regulatory mechanism that directly influences the function of tumour suppressors.

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Figure 1: Proposed models of monubiquitylation-mediated shuttling of tumour-suppressor proteins.

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Acknowledgements

We would like to thank all the members of the Pandolfi lab who contributed to these ideas. We are grateful to J.G. Clohessy and J. Kotsopoulos for critically reviewing the manuscript. We apologize to those colleagues whose work could not be included owing to space limitations. The work of P.P.P. is supported by the US National Cancer Institute, L.S. is supported by a Long Term Fellowship from the Human Frontier Science Program.

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  1. Leonardo Salmena and Pier Paolo Pandolfi are at the Cancer Biology and Genetics Program and Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.,

    Leonardo Salmena & Pier Paolo Pandolfi

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  1. Leonardo Salmena
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  2. Pier Paolo Pandolfi
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Correspondence to Pier Paolo Pandolfi.

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Salmena, L., Pandolfi, P. Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation. Nat Rev Cancer 7, 409–413 (2007). https://doi.org/10.1038/nrc2145

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