Abstract
The practise of Systems Biology relies on interfaces. Interfaces between the entities we study: the paradigm moved from a physical object centric view toward a relationship-centric one; interfaces between tools: From the retrieval of the primary data to the fine analysis of a model's behaviour, one uses many tools, more or less well connected; interfaces between individuals: To build any non-trivial mechanistic model requires to merge existing work and gather external expertise.If we want these interfaces to be generic enough to allow for anybody to leverage on existing toolkits, a fundamental requirement is the existence of community-developed well supported standards, but also open resources where to find the "lego" blocks. Over the last half-decade, several efforts have been launched in that direction,whether concerning encoding format, ontologies or databases. Some of them are now well-established in the field and play a significant role to improve its coherence but also to increase the size and the quality of quantitative models.
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Le Novere, N. Open Standards and Resources in Systems Biology: collaborative scale-up toward virtual life. Nat Prec (2006). https://doi.org/10.1038/npre.2006.10.1
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DOI: https://doi.org/10.1038/npre.2006.10.1