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Young neurons for old brains?

Nature Neuroscience volume 1, pages 645–647 (1998)Cite this article

Abstract

New evidence suggests that embryonic progenitor cells in the adult human hippocampus can generate new neurons; the results raise the possibility of therapeutic neuron replacement.

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Figure 1: Newly generated neuron in adult human dentate gyrus.
Figure 2: Schematic drawing showing the location of the hippocampal formation in the temporal lobe of the human brain where double-labeled cells, indicating recently generated neurons, were found.

References

  1. Rakic, P. Science 227, 154–156 ( 1985).

    Article  Google Scholar 

  2. Ericksson, S. E. et al. Nat. Med. 4, 1313– 1317 (1998). See http://neurosci.nature.com/web_specials/supp_info/nm1198_1313/ for fulltext of article.

    Article  Google Scholar 

  3. Altman, J. & Bayer, S. A. Restorative Neurol. 6, 203–225 (1993).

    Google Scholar 

  4. Lois C, & Alvarez-Buylla, A. Science 264, 1145–1148 (1994).

    Article  CAS  Google Scholar 

  5. Kempermann, G., Kuhn, H. G. & Gage, F. H. Proc. Natl. Acad. Sci. USA 94, 10409–10414 (1997).

    Article  CAS  Google Scholar 

  6. Kuhn, H. G., Dickinson-Anson, H. & Gage, F. H. J. Neurosci. 16, 2027– 2033 (1996).

    Article  CAS  Google Scholar 

  7. Kempermann, G., Kuhn, H. G. & Gage, F. H. Nature 386, 493– 495 (1997).

    Article  CAS  Google Scholar 

  8. Eckenhoff, M. E. & Rakic, P. J. Neurosci. 8, 2729–2747 (1988).

    Article  CAS  Google Scholar 

  9. Kirschenbaum, B. et al. Cereb. Cortex 4, 576– 589 (1994).

    Article  CAS  Google Scholar 

  10. Gould, E. et al. Proc. Natl. Acad. Sci. USA 95, 3168– 3171 (1998).

    Article  CAS  Google Scholar 

  11. Nottebohm, F. & Alvarez-Buylla, A. Restorative Neurol. 6, 227–236 (1993).

    Google Scholar 

  12. Rakic, P. Science l83, 425–427 (l974).

  13. Flax, J. D. Nat. Biotechnol. 16, 1033–1039 (1998).

    Article  CAS  Google Scholar 

  14. Brustle, O. Nat. Biotechnol. 16, 1040–1044 (1998).

    Article  CAS  Google Scholar 

  15. Rakic, P. Science 241, 170–176 ( 1988).

    Article  CAS  Google Scholar 

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  1. the Section of Neurobiology, Yale University School of Medicine, New Haven, 06510, Connecticut , USA

    Pasko Rakic

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  1. Pasko Rakic
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Rakic, P. Young neurons for old brains?. Nat Neurosci 1, 645–647 (1998). https://doi.org/10.1038/3643

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