Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Stringing the fiddle: the inner ear's two-part invention

An Erratum to this article was published on 01 December 2007

This article has been updated

The identity of the tip link, which converts mechanical force to channel opening in hair cells, has been controversial, with different groups promoting cadherin 23 or protocadherin 15. A new paper in Nature shows that both proteins are involved.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Structure of hair bundle stereocilia and tip links.

Change history

  • 23 October 2007

    In the version of this article initially published, the legends for Figure 1d and f were switched, and citations to these panels in the text were incorrect. In addition, references to specific animal models in ref. 10 were inaccurate. The errors have been corrected in the HTML and PDF versions of the article.

References

  1. Kazmierczak, P. et al. Nature 449, 87–91 (2007).

    Article  CAS  Google Scholar 

  2. Kachar, B., Parakkal, M., Kurc, M., Zhao, Y. & Gillespie, P.G. Proc. Natl. Acad. Sci. USA 97, 13336–13341 (2000).

    Article  CAS  Google Scholar 

  3. Bork, J.M. et al. Am. J. Hum. Genet. 68, 26–37 (2001).

    Article  CAS  Google Scholar 

  4. Di Palma, F. et al. Nat. Genet. 27, 103–107 (2001).

    Article  CAS  Google Scholar 

  5. Sollner, C. et al. Nature 428, 955–959 (2004).

    Article  Google Scholar 

  6. Ahmed, Z.M. et al. Am. J. Hum. Genet. 69, 25–34 (2001).

    Article  CAS  Google Scholar 

  7. Alagramam, K.N. et al. Nat. Genet. 27, 99–102 (2001).

    Article  CAS  Google Scholar 

  8. Seiler, C. et al. Development (2005).

  9. Siemens, J. et al. Nature 428, 950–955 (2004).

    Article  CAS  Google Scholar 

  10. Michel, V. et al. Dev. Biol. 280, 281–294 (2005).

    Article  CAS  Google Scholar 

  11. Goodyear, R.J. & Richardson, G.P. J. Neurosci. 23, 4878–4887 (2003).

    Article  CAS  Google Scholar 

  12. Ahmed, Z.M. et al. J. Neurosci. 26, 7022–7034 (2006).

    Article  CAS  Google Scholar 

  13. Senften, M. et al. J. Neurosci. 26, 2060–2071 (2006).

    Article  CAS  Google Scholar 

  14. Adato, A. et al. Hum. Mol. Genet. 14, 347–356 (2005).

    Article  CAS  Google Scholar 

  15. Patel, S.D. et al. Cell 124, 1255–1268 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Corey, D. Stringing the fiddle: the inner ear's two-part invention. Nat Neurosci 10, 1232–1233 (2007). https://doi.org/10.1038/nn1007-1232

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn1007-1232

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing