Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Long-term depression with a flash

Nature Neuroscience volume 1, pages 89–90 (1998)Cite this article

Abstract

The site of expression of hippocampal synaptic plasticity has been hotly debated. A new study demonstrates that postsynaptic neurons alone can express long-term depression.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: A hippocampal CA1 pyramidal cell is bathed in caged glutamate.

References

  1. Malenka, R.C. Cell 78, 535–538 (1994)

    Article  CAS  Google Scholar 

  2. Bear, M.F. & Abraham, W.C. Annu. Rev. Neurosci. 19, 437–462 (1996)

    Article  CAS  Google Scholar 

  3. Zola-Morgan, S. & Squire, L.R. Annu. Rev. Neurosci. 16, 547–56 (1993)

    Article  CAS  Google Scholar 

  4. Kandler, K., Katz, L.C. & Kauer, J.A. Nature Neurosci. 1, 119–123 (1998)

    Article  CAS  Google Scholar 

  5. Lisman, J. Proc. Natl Acad. Sci. USA 86, 9574–9578 ( 1989)

    Article  CAS  Google Scholar 

  6. Nicoll, R.A. & Malenka, R.C. Nature 377, 115–118 (1995)

    Article  CAS  Google Scholar 

  7. Larkman, A.U. & Jack, J.J. Curr. Opin. Neurobiol. 5, 324–334 (1995)

    Article  CAS  Google Scholar 

  8. Kullmann, D.M. & Siegelbaum, S.A. Neuron 15, 997–1002 (1995)

    Article  CAS  Google Scholar 

  9. Mulkey, R.M. & Malenka, R.C. Neuron 9, 967–975 (1992)

    Article  CAS  Google Scholar 

  10. Dudek, S.M. & Bear, M.F. Proc. Natl Acad. Sci. USA 89, 4363–4367 (1992)

    Article  CAS  Google Scholar 

  11. Mulkey, R.M., Herron, C.E. & Malenka, R.C. Science 261, 1051– 1055 (1993)

    Article  CAS  Google Scholar 

  12. Malenka, R.C. & Nicoll, R.A. Trends Neurosci. 16 , 521–527 (1993)

    Article  CAS  Google Scholar 

  13. Davies S.N., Lester, R.A.J., Reymann, K.G. & Collingridge, G.L. Nature 338, 500–503 ( 1989)

    Article  CAS  Google Scholar 

  14. Oliet, S.H.R., Malenka, R.C. & Nicoll, R.A. Science 271, 1294– 1297 (1996)

    Article  CAS  Google Scholar 

  15. Barria, A., Muller, D., Derkach, V., Griffith, L.C. & Soderling, T.R. Science 276, 2042– 2045 (1997)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept. of Psychiatry, University of California, San Francisco, 94143, California, USA

    Robert Malenka

  2. Dept. of Physiology, University of California, San Francisco, 94143, California, USA

    Robert Malenka

  3. Dept. of Cellular and Molecular Pharmacology, University of California, San Francisco, 94143, California, USA

    Roger Nicoll

  4. Dept. of Physiology, University of California, San Francisco, 94143, California, USA

    Roger Nicoll

Authors
  1. Robert Malenka
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Roger Nicoll
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Robert Malenka or Roger Nicoll.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Malenka, R., Nicoll, R. Long-term depression with a flash. Nat Neurosci 1, 89–90 (1998). https://doi.org/10.1038/333

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/333

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing