A study shows that NR3A–containing presynaptic NMDA receptors regulate glutamate release, and that a switch in subunit composition underlies the developmental loss of spike timing–dependent LTD at cortical synapses.
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Buonanno, A. Presynaptic NMDA receptors also make the switch. Nat Neurosci 14, 274–276 (2011). https://doi.org/10.1038/nn0311-274
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DOI: https://doi.org/10.1038/nn0311-274
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Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain
Nature Communications (2022)