How activity-dependent synaptic plasticity shapes the development of inhibitory synapses has remained unclear. In this issue, Gillespie et al. show that in the developing rat auditory system, inhibitory synapses transiently co-release glutamate. The consequent activation of postsynaptic NMDA receptors may be critical for the plasticity mechanisms that determine tonotopic sharpening.
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Kauer, J. Inhibitory synapses turn exciting. Nat Neurosci 8, 257–258 (2005). https://doi.org/10.1038/nn0305-257
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DOI: https://doi.org/10.1038/nn0305-257