The opioid receptor–like receptor inhibits the Cav2.2 calcium channel even without the receptor ligand, nociceptin. A new study finds that long-term exposure to nociceptin causes internalization of the receptor-channel complex.
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Lipscombe, D., Raingo, J. Internalizing channels: a mechanism to control pain?. Nat Neurosci 9, 8–10 (2006). https://doi.org/10.1038/nn0106-8
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DOI: https://doi.org/10.1038/nn0106-8
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