Developmental knockdown of Shank3 affects excitatory synaptic transmission, activity of midbrain dopamine neurons, and behavior. Optogenetic dopamine release or enhancing metabotropic glutamate receptor signaling rescues these deficits.
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Priest, M., Kozorovitskiy, Y. PAM helps solve VTA's SHANKless problem. Nat Neurosci 19, 864–866 (2016). https://doi.org/10.1038/nn.4336
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DOI: https://doi.org/10.1038/nn.4336
