Abstract
In the vibrissal system, touch information is conveyed by a receptorless whisker hair to follicle mechanoreceptors, which then provide input to the brain. We examined whether any processing, that is, meaningful transformation, occurs in the whisker itself. Using high-speed videography and tracking the movements of whiskers in anesthetized and behaving rats, we found that whisker-related morphological phase planes, based on angular and curvature variables, can represent the coordinates of object position after contact in a reliable manner, consistent with theoretical predictions. By tracking exposed follicles, we found that the follicle-whisker junction is rigid, which enables direct readout of whisker morphological coding by mechanoreceptors. Finally, we found that our behaving rats pushed their whiskers against objects during localization in a way that induced meaningful morphological coding and, in parallel, improved their localization performance, which suggests a role for pre-neuronal morphological computation in active vibrissal touch.
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Acknowledgements
We thank D. Goldian and S. Haidarliu for technical assistance, N. Rubin for programming, B. Schick for reviewing, M. Hartmann and J. Solomon for critically reading the manuscript and for extensive and helpful discussions, and C. Moore, J. Ritt, L. Gomez, S. Barash and G. Bi for helpful suggestions. The article is dedicated to our late friend and colleague Maciej Pietr for his significant contribution to this work. This work was supported by the Israel Science Foundation (grant 749/10), the Minerva Foundation funded by the Federal German Ministry for Education and Research, the United States–Israel Binational Science Foundation (grant 2011432), the Ministry of Science and Technology (Israel), the Ministry of Research (Taiwan), and the Chief Scientist, Israeli Ministry of Health. K.B. acknowledges support by the KAMEA program administered by the Ministry of Absorption (Israel). P.M.K. was supported by a Long-Term Fellowship from the Human Frontier Science Program. E.A. holds the Helen Diller Family Professorial Chair of Neurobiology.
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K.B. and M.S. performed the artificial whisking experiments. K.B. designed and K.B. and M.S. performed the exposed follicle experiments. P.M.K., D. Deutsch and M.P. performed the head-fixed and freely moving experiments. K.B., M.S., P.M.K., D. Deutsch, D. Derdikman and E.S. analyzed data. K.B., M.S., P.M.K., D. Deutsch, D. Derdikman, E.S. and E.A. prepared figures. K.B., M.S., P.M.K., D. Deutsch, D. Derdikman and E.A. wrote the manuscript.
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Supplementary Text and Figures
Supplementary Figure 1 (PDF 16 kb)
Supplementary Movie 1
Freely-moving rat (single whisker) (AVI 4463 kb)
Supplementary Movie 2
Freely-moving rat (intact pad) (AVI 2747 kb)
Supplementary Movie 3
Head-fixed rat (AVI 869 kb)
Supplementary Movie 4
Follicle-whisker dynamics (MOV 9554 kb)
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Bagdasarian, K., Szwed, M., Knutsen, P. et al. Pre-neuronal morphological processing of object location by individual whiskers. Nat Neurosci 16, 622–631 (2013). https://doi.org/10.1038/nn.3378
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DOI: https://doi.org/10.1038/nn.3378
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