Pathological alterations in Alzheimer's disease disrupt neuronal network function. An in vivo imaging study using a fluorescent reporter of neuronal activity finds dysfunction specifically in those neurons near amyloid plaques.
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Dorostkar, M., Herms, J. Arc illuminates Alzheimer's pathophysiology. Nat Neurosci 15, 1323–1325 (2012). https://doi.org/10.1038/nn.3226
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DOI: https://doi.org/10.1038/nn.3226
