Abstract
Although the clarity of many memories fades with time, some memories may maintain their original precision. Here we used a context discrimination procedure to evaluate whether the hippocampus is important in maintaining precision as memories mature. Spared discrimination in hippocampal-lesioned mice indicated that precise, remote context memories may be supported by extra-hippocampal brain regions.
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Acknowledgements
We thank S. Josselyn, B. Wiltgen and A. Corvelo for comments on this manuscript. This work was supported by grants from the Canadian Institutes of Health Research (MOP-77561) and the EJLB Foundation (P.W.F.). C.M.T. and A.L.W. received support from the Ontario Ministry of Research and Innovation and the Ontario Mental Health Foundation, respectively.
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S.-H.W. and P.W.F. conceived and designed the experiments. S.-H.W., C.M.T. and A.L.W. performed the behavioral studies and carried out the statistical analyses. S.-H.W. conducted the lesions and histological analyses. P.W.F. supervised the project and wrote the paper with S.-H.W.
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Supplementary Figures 1–4, Supplementary Methods, Supplementary Results and Supplementary Note (PDF 2851 kb)
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Wang, SH., Teixeira, C., Wheeler, A. et al. The precision of remote context memories does not require the hippocampus. Nat Neurosci 12, 253–255 (2009). https://doi.org/10.1038/nn.2263
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DOI: https://doi.org/10.1038/nn.2263
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