By fusing a light-sensitive domain of an oat plant protein to Rac1, researchers created a genetically encoded protein fusion that can be reversibly activated with blue light and control cell movement—an attractive alternative to current caging tools.
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References
Machacek, M. et al. Coordination of Rho GTPase activities during cell protrusion. Nature 461, 99–103 (2009).
Wu, Y. I. et al. A genetically encoded photoactivatable Rac controls the motility of living cells. Nature 461, 104–108 (2009).
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Kaganman, I. 'Blue' lighting cell signaling research. Nat Methods 6, 694–695 (2009). https://doi.org/10.1038/nmeth1009-694a
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DOI: https://doi.org/10.1038/nmeth1009-694a
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