Abstract
RNA interference (RNAi) and automated high-throughput screening is a promising combination. But the first systematic large-scale mapping of genetic interactions in an animal shows that manual methods still have advantages over sophisticated automated screens.
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References
Lehner, B. et al. Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways. Nat. Genetics 38, 896–903 (2006).
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Evanko, D. In praise of manual high-throughput screening. Nat Methods 3, 662–663 (2006). https://doi.org/10.1038/nmeth0906-662b
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DOI: https://doi.org/10.1038/nmeth0906-662b