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Making mice at high speed

Nature Methods volume 4, pages 196–197 (2007)Cite this article

Abstract

Laser-assisted injection of embryonic stem cells (ESC) into 8-cell stage embryos yields mice that are fully ESC-derived.

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Figure 1: Comparison of two techniques to generate transgenic mice.

References

  1. Valenzuela, D.M. et al. High-throughput engineering of the mouse genome coupled with high-resolution expression analysis. Nat. Biotechnol. 21, 652–659 (2003).

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  2. Poueymirou, W.T. et al. F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses. Nat. Biotechnol. 25, 91–99 (2007).

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Authors
  1. Nicole Rusk
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Rusk, N. Making mice at high speed. Nat Methods 4, 196–197 (2007). https://doi.org/10.1038/nmeth0307-196a

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  • DOI: https://doi.org/10.1038/nmeth0307-196a

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