Abstract
Using a line-scanning method during functional magnetic resonance imaging (fMRI), we obtained high temporal (50-ms) and spatial (50-μm) resolution information along the cortical thickness and showed that the laminar position of fMRI onset coincides with distinct neural inputs in rat somatosensory and motor cortices. This laminar-specific fMRI onset allowed us to identify the neural inputs underlying ipsilateral fMRI activation in the barrel cortex due to peripheral denervation-induced plasticity.
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Acknowledgements
This research was supported by the Intramural Research Program of the US National Institutes of Health–NINDS. We thank K. Sharer and N. Bouraoud for technical support.
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X.Y. and A.P.K. conceived of the line-scanning strategy and designed experiments. X.Y. established the line-scanning method, performed experiments and analyzed the data. C.Q. and D.-y.C. performed blind experiments on the MEMRI tracing and line-scanning fMRI of the plasticity model. S.J.D. provided magnetic resonance technical support and IDL (Interactive Data Language) analytical tools. X.Y. and A.P.K. wrote the paper.
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Yu, X., Qian, C., Chen, Dy. et al. Deciphering laminar-specific neural inputs with line-scanning fMRI. Nat Methods 11, 55–58 (2014). https://doi.org/10.1038/nmeth.2730
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DOI: https://doi.org/10.1038/nmeth.2730
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