Nanoparticle-based imaging plays a crucial role in cancer diagnosis and treatment. Here, we discuss the modalities used for molecular imaging of the tumour microenvironment and image-guided interventions including drug delivery, surgery and ablation therapy.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hamburg, M. A. & Collins, F. S. N. Engl. J. Med. 363, 301–304 (2010).
ZámeÄŤnĂkova, A. Expert Opin. Drug Discov. 9, 77–92 (2014).
Mankoff, D. A. J. Nucl. Med. 48, 18N–21N (2007).
Blasberg, R. & Piwnica-Worms, D. Clin. Cancer. Res. 18, 631–637 (2012).
Pysz, M. A., Gambhir, S. S. & Willmann, J. K. Clin. Radiol. 65, 500–516 (2010).
Weissleder, R., Kelly, K., Sun, E. Y., Shtatland, T. & Josephson, L. Nature Biotechnol. 23, 1418–1423 (2005).
Vera, D. R., Wallace, A. M., Hoh, C. K. & Mattrey, R. F. J. Nucl. Med. 42, 951–959 (2001).
Sondak, V. et al. Ann. Surg. Oncol. 20, 680–688 (2013).
Hanahan, D. & Weinberg, R. A. Cell 144, 646–674 (2011).
Hurwitz, H. et al. N. Engl. J. Med. 350, 2335–2342 (2004).
Morales-Avila, E. et al. Bioconjug. Chem. 22, 913–922 (2011).
Yang, X. et al. Biomaterials 32, 4151–4160 (2011).
Chen, F. et al. ACS Nano 7, 9027–9039 (2013).
Pochon, S. et al. Invest. Radiol. 45, 89–95 (2010).
Deshpande, N., Ren, Y., Foygel, K., Rosenberg, J. & Willmann, J. K. Radiology 258, 804–811 (2011).
Kiessling, F., Fokong, S., Koczera, P., Lederle, W. & Lammers, T. J. Nucl. Med. 53, 345–348 (2012).
Lu, W. et al. Cancer. Res. 71, 6116–6121 (2011).
Schmieder, A. H. et al. Radiology 268, 470–480 (2013).
Bolley, J. et al. Nanoscale 5, 11478–11489 (2013).
Corot, C. & Warlin, D. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 5, 411–422 (2013).
Hak, S. et al. Angiogenesis 17, 93–107 (2014).
Brabletz, T., Lyden, D., Steeg, P. S. & Werb, Z. Nature Med. 19, 1104–1109 (2013).
Weissleder, R., Nahrendorf, M. & Pittet, M. Nature Mater. 13, 125–138 (2014).
Melancon, M. P. et al. Biomaterials 31, 6567–6573 (2010).
Lanza, G. M. et al. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 6, 1–14 (2013).
Rosen, J. E., Chan, L., Shieh, D.-B. & Gu, F. X. Nanomed. Nanotechnol. Biol. 8, 275–290 (2012).
Wu, L., Cao, Y., Liao, C., Huang, J. & Gao, F. Eur. J. Radiol. 80, 582–589 (2011).
Harisinghani, M. G. et al. N. Engl. J. Med. 348, 2491–2499 (2003).
Wang, Y.-X. J. Quant. Imaging. Med. Surg. 1, 35–40 (2011).
Ferrari, M. Nature Rev. Cancer 5, 161–171 (2005).
Chauhan, V. & Jain, R. K. Nature Mater. 12, 958–962 (2013).
Choi, H. S. et al. Nature Biotechnol. 25, 1165–1170 (2007).
Kim, B. H. et al. J. Am. Chem. Soc. 133, 12624–12631 (2011).
Choi, H. S. & Frangioni, J. V. Mol. Imaging 9, 291–310 (2010).
Lee, C.-M. et al. J. Nucl. Med. 54, 1974–1980 (2013).
Unnikrishnan, S. & Klibanov, A. L. Am. J. Roentgenol. 199, 292–299 (2012).
Sheeran, P. S. & Dayton, P. A. Curr. Pharm. Des. 18, 2152–2165 (2012).
Sheeran, P. S., Luois, S. H., Mullin, L. B., Matsunaga, T. O. & Dayton, P. A. Biomaterials 33, 3262–3269 (2012).
Von Maltzahn, G. et al. Nature Mater. 10, 545–552 (2011).
Zhang, H.-W. et al. Biomaterials 35, 356–367 (2014).
Cassidy, M. C., Chan, H. R., Ross, B. D., Bhattacharya, P. K. & Marcus, C. M. Nature Nanotech. 8, 363–368 (2013).
Cheng, Z., Al Zaki, A., Hui, J. Z., Muzykantov, V. R. & Tsourkas, A. Science 338, 903–910 (2012).
Orosco, R. K., Tsien, R. Y. & Nguyen, Q. T. IEEE Rev. Biomed. Eng. 6, 178–187 (2013).
Stummer, W. et al. Lancet Oncol. 7, 392–401 (2006).
Sakuma, S. et al. Eur. J. Pharm. Biopharm. 79, 537–543 (2011).
Garai, E. et al. J. Biomed. Optics 18, 096008 (2013).
Jokerst, J. V., Cole, A. J., Van de Sompel, D. & Gambhir, S. S. ACS Nano 6, 10366–10377 (2012).
Zhang, R. et al. J. Nucl. Med. 52, 958–964 (2011).
Ali, Z. et al. Anal. Chem. 83, 2877–2882 (2011).
Cha, E.-J. et al. J. Control. Release 155, 152–158 (2011).
Olson, E. S. et al. Proc. Natl Acad. Sci. USA 107, 4311–4316 (2010).
Kircher, M. F. et al. Nature Med. 18, 829–834 (2012).
Ibsen, S., Schutt, C. E. & Esener, S. Drug Des. Devel. Ther. 7, 375–388 (2013).
Chen, K.-J. et al. ACS Nano 7, 438–446 (2012).
You, J. et al. Cancer. Res. 72, 4777–4786 (2012).
You, J. et al. J. Control. Release 158, 319–328 (2012).
Hong, C. W., Libutti, S. K. & Wood, B. J. Curr. Oncol. 20, e274–e277 (2013).
Melancon, M. P. et al. Invest. Radiol. 46, 132–140 (2011).
Hijnen, N. M., de Vries, A., Nicolay, K. & Grüll, H. Contrast Media Mol. Imaging 7, 214–222 (2012).
Lee, H. J. et al. J. Control. Release 172, 152–158 (2013).
Zou, P., Chen, H., Paholak, H. J. & Sun, D. Mol. Pharm. 10, 4185–4194 (2013).
Langereis, S. et al. J. Am. Chem. Soc. 131, 1380–1381 (2009).
Rieke, V. & Butts Pauly, K. J. Magn. Reson. Imaging 27, 376–390 (2008).
Roizin-Towle, L. & Pirro, J. P. Int. J. Radiat. Oncol. Biol. Phys. 20, 751–756 (1991).
Dewhirst, M. W., Viglianti, B. L., Lora-Michiels, M., Hanson, M. & Hoopes, P. J. Int. J. Hyperthermia 19, 267–294 (2003).
Sapareto, S. A. & Dewey, W. C. Int. J. Radiat. Oncol. Biol. Phys. 10, 787–800 (1984).
Fahrenholtz, S. J., Stafford, R. J., Maier, F., Hazle, J. D. & Fuentes, D. Int. J. Hyperthermia 29, 324–335 (2013).
Gasselhuber, A. et al. Int. J. Hyperthermia 26, 499–513 (2010).
Dothager, R. S. & Piwnica-Worms, D. Cancer. Res. 71, 5611–5615 (2011).
Acknowledgements
I would like to thank Dr. David Piwnica-Worms for helpful discussions. This work was supported in part by the National Cancer Institute (U54CA151668 and R01CA119387), the Viragh Family Foundation and the John S. Dunn Foundation.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Li, C. A targeted approach to cancer imaging and therapy. Nature Mater 13, 110–115 (2014). https://doi.org/10.1038/nmat3877
Published:
Issue Date:
DOI: https://doi.org/10.1038/nmat3877