Holt–Oram syndrome has been associated with mutations in the T-box transcription factor TBX5, but little is known about the function of this protein or how mutations in it cause disease. A new mouse model of this syndrome will help to answer some of these questions.
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Hatcher, C., Basson, C. Getting the T-box dose right. Nat Med 7, 1185–1186 (2001). https://doi.org/10.1038/nm1101-1185
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DOI: https://doi.org/10.1038/nm1101-1185
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