Aberrant activation of the protein phosphatase calcineurin is found in various cancer types. Inhibition of calcineurin leads to a rapid clearance of leukemic cells and significantly improves animal survival in two mouse models of acute T lymphoblastic leukemia.
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A.R. is scientific founder of a company, Calcimedica, that seeks to identify novel treatments for immune-related diseases.
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Müller, M., Rao, A. Linking calcineurin activity to leukemogenesis. Nat Med 13, 669–671 (2007). https://doi.org/10.1038/nm0607-669
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DOI: https://doi.org/10.1038/nm0607-669
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