AMP-activated protein kinase has a crucial role in coupling substrate availability with substrate oxidation in skeletal muscle. Recent findings suggest that this biochecmical fuel sensor also participates in the hypothalmic recognition of the body's energy status.
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Pocai, A., Muse, E. & Rossetti, L. Did a muscle fuel gauge conquer the brain?. Nat Med 12, 50–51 (2006). https://doi.org/10.1038/nm0106-50
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DOI: https://doi.org/10.1038/nm0106-50