Cytokines secreted during tissue damage and inflammation can trigger the formation of fibrous tissue. The cytokine IL-13 is now shown to induce TGF-β, the major fibrotic cytokine. IL-13 does so through a receptor previously thought to relay no signal (pages 99–106).
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MacDonald, T. Decoy receptor springs to life and eases fibrosis. Nat Med 12, 13–14 (2006). https://doi.org/10.1038/nm0106-13
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DOI: https://doi.org/10.1038/nm0106-13
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