The clot-busting drug tissue plasminogen activator (tPA) is currently the only FDA-approved therapy for acute stroke. However, increasing evidence suggests that tPA can also contribute to excitotoxic neuronal damage in animal models of stroke. (pages 59–64)
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Traynelis, S., Lipton, S. Is tissue plasminogen activator a threat to neurons?. Nat Med 7, 17–18 (2001). https://doi.org/10.1038/83289
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DOI: https://doi.org/10.1038/83289
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