How B cell tolerance is retained during somatic hypermutation in germinal centers is incompletely understood. Two studies now show that Foxp3+ regulatory T cells undergo functional specialization to limit the magnitude of the germinal center response, and they may contribute to our understanding of how germinal center–mediated autoimmunity is prevented (pages 975–982 and 983–988).
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Campbell, D., Koch, M. Treg cells: patrolling a dangerous neighborhood. Nat Med 17, 929–930 (2011). https://doi.org/10.1038/nm.2433
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DOI: https://doi.org/10.1038/nm.2433