Peroxisome proliferator-activated receptors (PPARs) are important transcriptional regulators of genes involved in energy metabolism. Hydrolysis of cardiac lipid droplets by adipose triglyceride lipase (ATGL) is now shown to be required for PPAR-mediated gene regulation and mitochondrial function, suggesting new therapeutic possibilities for neutral lipid storage disease caused by mutations in ATGL (also known as PNPLA2) (pages 1076–1085).
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Abel, E. A new twist in the function of the cardiac lipid droplet. Nat Med 17, 1045–1046 (2011). https://doi.org/10.1038/nm.2432
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DOI: https://doi.org/10.1038/nm.2432