Members of the SOCS (suppressor of cytokine signaling) family negatively regulate STAT transcription factors. The SOCS family member CIS is now shown to negatively regulate differentiation into the TH2 and TH9 subsets of helper T cells through negative regulation of STAT3, STAT5 and STAT6.
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Yoshimura, A. CIS: the late-blooming eldest son. Nat Immunol 14, 692–694 (2013). https://doi.org/10.1038/ni.2645
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DOI: https://doi.org/10.1038/ni.2645