Making causative connections between genotypic and phenotypic variation is a major challenge for geneticists engaged in the study of human disease. A study drawing this connection for a type 1 diabetes risk locus now demonstrates the importance of focusing on specific quantitative traits and studying them in normal subjects.
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References
Barrett, J.C. et al. Nat. Genet. 41, 703–707 (2009).
Barrett, J.C. et al. Nat. Genet. 40, 955–962 (2008).
Gregersen, P.K. & Olsson, L.M. Annu. Rev. Immunol. 27, 363–391 (2009).
Dendrou, C.A. Nat. Genet. 41, 1011–1015 (2009).
Lowe, C.E. et al. Nat. Genet. 39, 1074–1082 (2007).
Hayday, A.C. & Peakman, M. Nat. Immunol. 9, 575–580 (2008).
Davis, M.M. Immunity 29, 835–838 (2008).
Brand, O.J. et al. Clin. Endocrinol. 66, 508–512 (2007).
Hafler, D.A. et al. N. Engl. J. Med. 357, 851–862 (2007).
Malek, T.R. Annu. Rev. Immunol. 26, 453–479 (2008).
Setoguchi, R., Hori, S., Takahashi, T. & Sakaguchi, S. J. Exp. Med. 201, 723–735 (2005).
Oh, U. et al. Arch. Neurol. 66, 471–479 (2009).
Collins, F.S. & Manolio, T.A. Nature 445, 259 (2007).
Nejentsev, S., Walker, N., Riches, D., Egholm, M. & Todd, J.A. Science 324, 387–389 (2009).
Lee-Kirsch, M.A. et al. Nat. Genet. 39, 1065–1067 (2007).
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Gregersen, P. Closing the gap between genotype and phenotype. Nat Genet 41, 958–959 (2009). https://doi.org/10.1038/ng0909-958
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DOI: https://doi.org/10.1038/ng0909-958