A new study shows that a deletion-induced aberrant antisense transcript from a neighboring gene leads to methylation and silencing of the intact gene HBA2 (encoding human α-globin A2) in a family with α-thalassemia. Are there other chromosomal rearrangements that might turn off genes by such antisense-mediated cis-acting methylation?
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Weatherall, D.J. Nat. Rev. Genet. 2, 245–255 (2001).
Tufarelli, C. et al. Nat. Genet. 34, 157–165 (2003).
Higgs, D.R. et al. Semin. Hematol. 35, 93–104 (1998).
Barbour, V.M. et al. Blood 96, 800–807 (2000).
Allshire, R. Science 297, 1818–1819.
Mette, M.F. et al. EMBO J. 19, 5194–5201.
Volpe, T.A. et al. Science 297, 1833 (2002).
Zwart, R. et al. Genes Dev. 15, 2361–2366 (2001).
Sleutels, F. et al. Nature 415, 810–813 (2002).
Boumil, R.M. & Lee, J.T. Hum. Mol. Genet. 10, 2225–2232 (2001).
Kleinjan, D.A. & Van Heyningen, V. Hum. Mol. Genet. 7, 1611–1618 (1998).
Kleinjan, D.A. et al. Hum. Mol. Genet. 10, 2049–2059 (2001).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kleinjan, D., van Heyningen, V. Turned off by RNA. Nat Genet 34, 125–126 (2003). https://doi.org/10.1038/ng0603-125
Issue Date:
DOI: https://doi.org/10.1038/ng0603-125