Centrosome abnormalities are linked to genomic instability and are considered one possible cause of cancer. A recent study shows that 'abnormal' inactive centrosomes thought to be deleterious to cells actually provide an accurate backup mechanism to the G2/M checkpoint, allowing specific elimination of nuclei with damaged DNA.
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Sibon, O. Centrosomes as DNA damage regulators. Nat Genet 34, 6–7 (2003). https://doi.org/10.1038/ng0503-6
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DOI: https://doi.org/10.1038/ng0503-6
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