Two new studies show that the Fanconi anemia complementation group N results from biallelic mutations in PALB2, which encodes a recently identified interaction partner of the breast cancer susceptibility protein BRCA2. A third study shows that monoallelic PALB2 mutations are associated with breast cancer susceptibility, providing yet more links between Fanconi anemia, homologous recombination repair and cancer predisposition.
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References
Lobitz, S. & Velleuer, E. Nat. Rev. Cancer 6, 893–898 (2006).
Niedernhofer, L.J., Lalai, A.S. & Hoeijmakers, J.H. Cell 123, 1191–1198 (2005).
Xia, B. et al. Nat. Genet. 39, 159–161 (2007).
Reid, S. et al. Nat. Genet. 39, 162–164 (2007).
Xia, B. et al. Mol. Cell 22, 719–729 (2006).
Rahman, N. et al. Nat. Genet. 39, 165–167 (2007).
Patel, K.J. et al. Mol. Cell 1, 347–357 (1998).
Howlett, N.G. et al. Science 297, 606–609 (2002).
Pellegrini, L. & Venkitaraman, A. Trends Biochem. Sci. 29, 310–316 (2004).
Seal, S. et al. Nat. Genet. 38, 1239–1241 (2006).
Alter, B.P., Rosenberg, P.S. & Brody, L.C. J. Med. Genet. 44, 1–9 (2007).
Niedzwiedz, W. et al. Mol. Cell 15, 607–620 (2004).
Yamamoto, K. et al. Mol. Cell. Biol. 25, 34–43 (2005).
Bridge, W.L., Vandenberg, C.J., Franklin, R.J. & Hiom, K. Nat. Genet. 37, 953–957 (2005).
Mosedale, G. et al. Nat. Struct. Mol. Biol. 12, 763–771 (2005).
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Patel, K. Fanconi anemia and breast cancer susceptibility. Nat Genet 39, 142–143 (2007). https://doi.org/10.1038/ng0207-142
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DOI: https://doi.org/10.1038/ng0207-142
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