A new analysis of cancer genomes identifies a decrease in the mutation burden of exons, but not introns, as compared to expectation. This difference can be explained by preferential recruitment of the DNA mismatch repair machinery to a protein modification that marks exons.
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Youssoufian, H. et al. Nature 324, 380–382 (1986).
Carlson, J. et al. bioRxiv, preprint at https://doi.org/10.1101/108290 (2017).
Sabarinathan, R., Mularoni, L., Deu-Pons, J., Gonzalez-Perez, A. & López-Bigas, N. Nature 532, 264–267 (2016).
Perera, D. et al. Nature 532, 259–263 (2016).
Schuster-Böckler, B. & Lehner, B. Nature 488, 504–507 (2012).
Lawrence, M.S. et al. Nature 499, 214–218 (2013).
Haradhvala, N.J. et al. Cell 164, 538–549 (2016).
Jónsson, H. et al. Nature 549, 519–522 (2017).
Frigola, J. et al. Nat. Genet. 49, 1684–1692 (2017).
Li, J. et al. PLoS Comput. Biol. 11, e1004583 (2015).
Li, F. et al. Cell 153, 590–600 (2013).
Schwartz, S., Meshorer, E. & Ast, G. Nat. Struct. Mol. Biol. 16, 990–995 (2009).
King, M.C. & Wilson, A.C. Science 188, 107–116 (1975).
Supek, F. & Lehner, B. Cell 170, 534–547 (2017).
Imielinski, M., Guo, G. & Meyerson, M. Cell 168, 460–472 (2017).
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Massey, D., Koren, A. Mismatch repair prefers exons. Nat Genet 49, 1673–1674 (2017). https://doi.org/10.1038/ng.3993
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DOI: https://doi.org/10.1038/ng.3993