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Antipsychotics for aggressive behavior in patients with intellectual disability—an acceptable standard of care?

Nature Clinical Practice Neurology volume 4, pages 418–419 (2008)Cite this article

Tyrer P et al. (2008) Risperidone, haloperidol, and placebo in the treatment of aggressive challenging behaviour in patients with intellectual disability: a randomised controlled trial. Lancet 371: 57–63

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References

  1. Kahn M (online 3 January 2008) J&J drugs don't work in treating aggression: study [http://www.reuters.com/article/healthNews/idUSL0358278920080104] (accessed 29 May 2008)

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Acknowledgements

The synopsis was written by James Casey, Editorial Assistant, Nature Clinical Practice.

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Author notes

  1. LE Arnold is Professor Emeritus of Psychiatry at Ohio State University and Interim Director of The Nisonger Center, Columbus, OH, USA.

Authors and Affiliations

  1. E Tierney is Associate Professor of Psychiatry at Johns Hopkins University School of Medicine and Director of Psychiatry at Kennedy Krieger Institute, Baltimore, MD, USA.,

    Elaine Tierney & L Eugene Arnold

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  1. Elaine Tierney
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  2. L Eugene Arnold
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Corresponding author

Correspondence to Elaine Tierney.

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Competing interests

E Tierney was a site PI on the Research Units on Pediatric Psychopharmacology Autism Network (RUPP Autism Network) study of risperidone for irritability, aggression, and self-injury (funded by NIMH), in which 101 youth with autistic disorder, most of them with intellectual disability, were randomized to receive risperidone vs placebo and showed a large and significant benefit at 8 weeks (New Engl J Med [2002] 347: 314–321). She has received research funding from Autism Speaks and Cure Autism Now.

LE Arnold was a co-investigator on two RUPP Autism Network studies of risperidone for irritability, aggression, and self-injury in children with autism (funded by NIMH) and several industry studies of antipsychotics. He has had research funding from Autism Speaks, Cure Autism Now, Lilly, Neuropharm, Shire, Sigma Tau, and Targacept and consulted with, Neuropharm, Novartis, Organon, Shire and Targacept.

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Tierney, E., Arnold, L. Antipsychotics for aggressive behavior in patients with intellectual disability—an acceptable standard of care?. Nat Rev Neurol 4, 418–419 (2008). https://doi.org/10.1038/ncpneuro0850

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