Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Commentary
  • Published:

Smart drug discovery leveraging innovative technologies and predictive knowledge

Nature Chemical Biology volume 2, pages 646–648 (2006)Cite this article

By building on the successes of the past and leveraging both innovative technologies and predictive knowledge, scientists can develop smarter ways to create a molecular armamentarium of chemical and biological medicines.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: A view of a drug discovery road map illustrating some key multidisciplinary technologies that enable the development of (i) breakthrough medicines from promising clinical candidates and (ii) lead optimization and generation processes that are advanced relative to novel ligands.
Figure 2: A view of the predicted druggable genome as charted according to superfamilies and other major groups of proteins of potential correlation to disease.
Figure 3: Views of the three-dimensional structures of Abl kinase–complexed novel small-molecule inhibitors.

References

  1. Yakunin, A.F., Yee, A.A., Savchenko, A., Edwards, A.M. & Arrowsmith, C.H. Curr. Opin. Chem. Biol. 8, 42–48 (2004).

    Article  CAS  Google Scholar 

  2. Williams, S.P., Kuyper, L.F. & Pearce, K.H. Curr. Opin. Chem. Biol. 9, 371–380 (2005).

    Article  CAS  Google Scholar 

  3. McCammon, M.G. & Robinson, C.V. Curr. Opin. Chem. Biol. 8, 60–65 (2004).

    Article  CAS  Google Scholar 

  4. Schade, M. & Oschkinat, H. Curr. Opin. Drug Discov. Devel. 8, 365–373 (2005).

    CAS  PubMed  Google Scholar 

  5. Villar, H.O., Yan, J. & Hansen, M.R. Curr. Opin. Chem. Biol. 8, 387–391 (2004).

    Article  CAS  Google Scholar 

  6. Wlodawer, A. & Vondrasek, J. Annu. Rev. Biophys. Biomol. Struct. 27, 249–284 (1998).

    Article  CAS  Google Scholar 

  7. Berman, H.M. et al. Nucleic Acids Res. 28, 235–242 (2000).

    Article  CAS  Google Scholar 

  8. Schneider, G. & Fechner, U. Nat. Rev. Drug Discov. 4, 649–663 (2005).

    Article  CAS  Google Scholar 

  9. Alvarez, J.C. Curr. Opin. Chem. Biol. 8, 365–370 (2004).

    Article  CAS  Google Scholar 

  10. Oprea, T.I. & Matter, H. Curr. Opin. Chem. Biol. 8, 349–358 (2004).

    Article  CAS  Google Scholar 

  11. Jones, S. & Thornton, J.M. Curr. Opin. Chem. Biol. 8, 3–7 (2004).

    Article  CAS  Google Scholar 

  12. Egan, W.J., Walters, W.P. & Murcko, M.A. Curr. Opin. Drug Discov. Devel. 5, 540–549 (2002).

    CAS  PubMed  Google Scholar 

  13. Gohlke, H. & Klebe, G. Angew. Chem. Int. Edn Engl. 41, 2644–2676 (2002).

    Article  CAS  Google Scholar 

  14. Agrafiotis, D.K. et al. Nat. Rev. Drug Discov. 1, 337–346 (2002).

    Article  CAS  Google Scholar 

  15. Austin, C.P. Curr. Opin. Chem. Biol. 7, 511–515 (2003).

    Article  CAS  Google Scholar 

  16. Wang, S., Sim, T.B., Kim, Y.S. & Chang, Y.T. Curr. Opin. Chem. Biol. 8, 371–377 (2004).

    Article  CAS  Google Scholar 

  17. Jensen, O.N. Curr. Opin. Chem. Biol. 8, 33–41 (2004).

    Article  Google Scholar 

  18. Wang, L. & Schultz, P.G. Angew. Chem. Int. Edn Engl. 44, 34–66 (2004).

    Article  Google Scholar 

  19. Yan, Y. & Marriott, G. Curr. Opin. Chem. Biol. 7, 635–640 (2003).

    Article  CAS  Google Scholar 

  20. Miller, L.W. & Cornish, V.W. Curr. Opin. Chem. Biol. 9, 56–61 (2005).

    Article  CAS  Google Scholar 

  21. Zhu, H. & Snyder, M. Curr. Opin. Chem. Biol. 7, 55–63 (2003).

    Article  CAS  Google Scholar 

  22. Majmudar, C.Y. & Mapp, A.K. Curr. Opin. Chem. Biol. 9, 467–474 (2005).

    Article  CAS  Google Scholar 

  23. Manoharan, M. Curr. Opin. Chem. Biol. 8, 570–579 (2004).

    Article  CAS  Google Scholar 

  24. Kalume, D.E., Molina, H. & Pandey, A. Curr. Opin. Chem. Biol. 7, 64–69 (2003).

    Article  CAS  Google Scholar 

  25. Alaimo, P.J., Shogren-Knaak, M.A. & Shokat, K.M. Curr. Opin. Chem. Biol. 5, 360–367 (2001).

    Article  CAS  Google Scholar 

  26. Vieth, M., Sutherland, J.J., Robertson, D.H., Campbell, R.M. Drug Discov. Today 10, 839–846 (2005).

    Article  CAS  Google Scholar 

  27. Sawyer, T.K. et al. Med. Chem. 1, 293–319 (2005).

    Article  CAS  Google Scholar 

  28. Sebolt-Leopold, J.S. & English, J.M. Nature 441, 457–462 (2006).

    Article  CAS  Google Scholar 

  29. Daub, H., Specht, K. & Ulrich, A. Nat. Rev. Drug Discov. 3, 1001–1010 (2004).

    Article  CAS  Google Scholar 

  30. Carter, T.A. et al. Proc. Natl. Acad. Sci. USA 102, 11011–11016 (2005).

    Article  CAS  Google Scholar 

  31. Druker, B.J. N. Engl. J. Med. 354, 2594–2596 (2006).

    Article  CAS  Google Scholar 

  32. Tokarski, J.S. et al. Cancer Res. 66, 5790–5797 (2006).

    Article  CAS  Google Scholar 

  33. Nagar, B. et al. Cancer Res. 62, 4236–4243 (2002).

    CAS  PubMed  Google Scholar 

  34. Capdeville, R., Buchdunger, E., Zimmerman, J. & Matter, A. Nat. Rev. Drug Discov. 1, 493–502 (2002).

    Article  CAS  Google Scholar 

  35. Okram, B. et al. Chem. Biol. 13, 779–786 (2006).

    Article  CAS  Google Scholar 

  36. Hopkins, A.L. & Groom, C.R. Nat. Rev. Drug Discov. 1, 727–730 (2002).

    Article  CAS  Google Scholar 

  37. Weisberg, E. et al. Br. J. Cancer 94, 1765–1769 (2006).

    Article  CAS  Google Scholar 

  38. Quintas-Cardama, A. et al. Blood (in the press).

  39. Azam, M. et al. Proc. Natl. Acad. Sci. USA 103, 9244–9249 (2006).

    Article  CAS  Google Scholar 

  40. Young, M.A. et al. Cancer Res. 66, 1007–1014 (2006).

    Article  CAS  Google Scholar 

  41. Gumireddy, K. et al. Proc. Natl. Acad. Sci. USA 102, 1992–1997 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the Pfizer Research Technology Center, Cambridge, 02139, Massachusetts, USA

    Tomi K Sawyer

Authors
  1. Tomi K Sawyer
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sawyer, T. Smart drug discovery leveraging innovative technologies and predictive knowledge. Nat Chem Biol 2, 646–648 (2006). https://doi.org/10.1038/nchembio1206-646

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio1206-646

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing