The zebrafish has become a popular model organism to investigate many biological processes, in part owing to the combination of facile genetic manipulation and rapid, external embryonic development. The application of large-scale screening to identify chemical suppressors of a cancer-prone mutant highlights new technology for whole organism–based small-molecule discovery.
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Sidi, S., Look, A. Small molecules thwart crash and burn. Nat Chem Biol 1, 351–353 (2005). https://doi.org/10.1038/nchembio1205-351
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DOI: https://doi.org/10.1038/nchembio1205-351